Adenosine Dialdehyde (ADOX)
CAS No. 34240-05-6
Adenosine Dialdehyde (ADOX) ( Adenox; Adenosine, periodate oxidized; Periodate-oxidized adenosine; Adenosinedialdehyde )
Catalog No. M27526 CAS No. 34240-05-6
Adenosine dialdehyde is a purine nucleoside analogue. Adenosine dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 45 | Get Quote |
|
10MG | 58 | Get Quote |
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25MG | 86 | Get Quote |
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50MG | 149 | Get Quote |
|
100MG | 224 | Get Quote |
|
200MG | 336 | Get Quote |
|
500MG | 565 | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameAdenosine Dialdehyde (ADOX)
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NoteResearch use only, not for human use.
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Brief DescriptionAdenosine dialdehyde is a purine nucleoside analogue. Adenosine dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.
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DescriptionAdenosine dialdehyde is a purine nucleoside analogue. Adenosine dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.(In Vitro):Adenosine dialdehyde suppresses MNB cell replication in tissue culture (1.5 μM, 50% inhibition) .(In Vivo):Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice. Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals. Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity.
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SynonymsAdenox; Adenosine, periodate oxidized; Periodate-oxidized adenosine; Adenosinedialdehyde
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PathwayOthers
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TargetOther Targets
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RecptorTrypsin-like proteasomes;IFN-γ
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Research Area——
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Indication——
Chemical Information
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CAS Number34240-05-6
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Formula Weight265.2
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILESNc1ncnc2n(cnc12)C(OC(CO)C=O)C=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shadrin N, et al. Serine protease inhibitors interact with IFN-γ through up-regulation of FasR; a novel therapeutic strategy against cancer. Exp Cell Res. 2015 Jan 15;330(2):233-9.
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