Adenosine Dialdehyde (ADOX)

CAS No. 34240-05-6

Adenosine Dialdehyde (ADOX) ( Adenox; Adenosine, periodate oxidized; Periodate-oxidized adenosine; Adenosinedialdehyde )

Catalog No. M27526 CAS No. 34240-05-6

Adenosine dialdehyde is a purine nucleoside analogue. Adenosine dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 45 Get Quote
10MG 58 Get Quote
25MG 86 Get Quote
50MG 149 Get Quote
100MG 224 Get Quote
200MG 336 Get Quote
500MG 565 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Adenosine Dialdehyde (ADOX)
  • Note
    Research use only, not for human use.
  • Brief Description
    Adenosine dialdehyde is a purine nucleoside analogue. Adenosine dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.
  • Description
    Adenosine dialdehyde is a purine nucleoside analogue. Adenosine dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.(In Vitro):Adenosine dialdehyde suppresses MNB cell replication in tissue culture (1.5 μM, 50% inhibition) .(In Vivo):Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice. Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals. Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity.
  • Synonyms
    Adenox; Adenosine, periodate oxidized; Periodate-oxidized adenosine; Adenosinedialdehyde
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Trypsin-like proteasomes;IFN-γ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    34240-05-6
  • Formula Weight
    265.2
  • Molecular Formula
    ——
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Nc1ncnc2n(cnc12)C(OC(CO)C=O)C=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shadrin N, et al. Serine protease inhibitors interact with IFN-γ through up-regulation of FasR; a novel therapeutic strategy against cancer. Exp Cell Res. 2015 Jan 15;330(2):233-9.
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